Alzheimer’s for Amateurs

28 October 2026 edition

Alzheimer’s Starts Talking Years Before It Shows

Read it on Substack
Two hourglasses under the title ‘More warning, more time to act’: a tall one for a blood test turning positive at 60, about 20 years of warning, and a shorter one at 80, about 11 years of warning.
Generated illustration, Alzheimer’s for Amateurs

What’s inside

Feature

A blood test that estimates when symptoms start

How a WashU team turned one blood measurement into a rough countdown to Alzheimer’s symptoms, why age changes the countdown, and what years of warning could be used for.

The roundup

Sharp old brains, early clues and a test recall

New nerve cells in people over 80 with unusually good memory, warning signs hiding in medical records, and a blood-test recall.

Spotted in the Wild

Two supplements, checked

What’s actually known about methylene blue and lion’s mane, plus a caregiver’s audition worth watching.

Trial watch

Four updates, followed up

Starting Leqembi at home, a newly approved drug for agitation, a pill with results due in November, and a light-and-sound headset.

Caregiver reset

A longer out-breath

For the person doing the caring: a breathing pattern Stanford tested against meditation.