Dementia Prevention Is Turning Out to Be a Very Long Game.

Feature

Lead from decades ago may still count against the brain

Why lead stored in bone, not lead in the blood, lined up with Alzheimer’s risk in older Americans, and why the fix is the same old cleanup of paint, pipes and soil.

• Lead stored in bone tracked with Alzheimer’s risk; lead in blood did notResearch Index →

The roundup

Ways to delay, measured over decades

A speed exercise from a 1990s trial, still visible 20 years later, and a lifetime of reading and learning that came with a later diagnosis.

• Speed training in the 1990s came with fewer dementia diagnoses 20 years laterResearch Index →
• A lifetime of reading and learning came with a later Alzheimer’s diagnosisResearch Index →

The roundup

Better tests, and two leads from the lab

Blood tests that held up in six Latin American countries, an enzyme switched off in mice, and a cheap seizure drug that slowed sticky amyloid in cells.

• Alzheimer’s blood tests held up in six Latin American countriesResearch Index →
• Switching off the enzyme IDOL in neurons cut plaques in miceResearch Index →
• A cheap seizure drug kept neurons from making the stickiest amyloid, in mice and human cellsResearch Index →

Trial watch

Psychosis in Alzheimer’s

When to expect results for a schizophrenia pill being tested against the hallucinations and delusions many families live with.

• Cobenfy for psychosis in Alzheimer’s: results expected from early 2027Research Index →

Spotted in the Wild

A podcast hook, checked

What holds up, and what doesn’t, in a hit podcast’s claim that Alzheimer’s “starts in your 30s,” plus a short news segment worth watching.

• Study finds brain training games may help protect against dementiaResearch Index →

Caregiver reset

Twenty minutes somewhere green

For the person doing the caring: what a small study found about stress and time outdoors.

What we got wrong

Three corrections

Three claims in the September 29 edition that their sources don’t support, and what does hold up.