Research Index entry · Study
A protein complex that helps neurons dispose of tau
- Evidence
- Lab · human cells
- Source
- doi.org
- Added
- 11 September 2026
What it is
CRL5–SOCS4 is a protein complex that helps a neuron get rid of tau before tau forms tangles. A 2026 UCSF and UCLA study found it with a gene-by-gene search in lab-grown human neurons, and donated brains backed it up.
Where it stands
- Lab discovery
- Animal studies
- First studies in people
- Large trials
- Approved
A lab discovery. No drug targets it yet.
Update timeline
What changed
Newest first. Only changes to the subject itself appear here: new information, or something proven wrong.
- WatchingThe Scouts look again every Friday
Only new information or a correction shows up here, not another mention of the same thing.
- No changes yet
Nothing new or corrected since this entry was added.
Research connections
Why these belong together
A connection has to say what it adds. Shared keywords alone don’t count.
Study · Institutions
Super agers are less likely to carry APOE4Both ask why some brains hold up against damage that overwhelms others.
People · geneticsStudy · Journals
A protein released by tumors cleared plaques in miceBoth are about how the brain clears a harmful protein: tau here, amyloid there.
Mice